Thrombocytopenia affects plasmatic coagulation as measured by thrombelastography

[Inhibition of plasmatic coagulation: what is new?].

The major goal in the development of new anticoagulant drugs is a more effective action with less adverse effects. Until now the mainly used agents are heparin and phenprocoumon or warfarin. These drugs inhibit multiple coagulation factors in different stages of the coagulation cascade. Modern drug development and the knowledge about the molecular mechanisms of the coagulation cascade allow spe...

Hypocoagulability in Traumatic Brain Injury as Measured by Traditional Means and Thrombelastography

Hypocoagulability in Traumatic Brain Injury as Measured by Traditional Means and Thrombelastography Sherry L Sixta1, Jessica C Cardenas1,3, Ryan Kitagawa2, Charles E Wade1,3, John B Holcomb1,2 and Bryan A Cotton1,2* 1Departments of Surgery, The University of Texas Health Science Center at Houston, TX, USA 2Neurosurgery, The University of Texas Health Science Center at Houston, TX, USA 3The Cent...

Disseminated Intravascular Coagulation in a Case of Brucellosis Misdiagnosed as Thrombotic Thrombocytopenia Purpura

Carbon monoxide and iron modulate plasmatic coagulation in Alzheimer's disease.

Alzheimer's disease (AD) is a significant source of morbidity and mortality for millions of people worldwide, and multiple potential etiologies have been postulated to contribute to AD. Among these, spontaneous cerebral emboli and increased cerebral and circulating heme oxygenase (Hmox) activity in AD patients are of particular interest, as two of the products of Hmox activity, carbon monoxide ...

Coagulation monitoring during extracorporeal membrane oxygenation: the role of thrombelastography.

Patients undergoing extracorporeal membrane oxygenation (ECMO) are at an increased risk for developing coagulopathies due to the adverse effects of extracorporeal circulation on the hemostatic mechanism. Methods of determining causative factors of bleeding diathesis are often inconsistent and non-specific. ECMO patients require aggressive transfusion therapy with autogenic blood products to sta...